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A few non-dietary studies have reported adverse effects in the gastrointestinal tract of laboratory animals given food-grade TiO2. However, these same effects were not seen when the same or higher doses of food-grade TiO2 were administered in the animals' diet. Dietary studies best reflect how humans are exposed to TiO2 from food. Thus, the Food Directorate placed the most emphasis on the results of these studies in the state of the science report.

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Global economic conditions also play a crucial role in determining the price of titanium dioxide per ton. During times of economic growth, demand for consumer goods that use titanium dioxide, such as paint and plastics, tends to increase, leading to higher prices During times of economic growth, demand for consumer goods that use titanium dioxide, such as paint and plastics, tends to increase, leading to higher prices During times of economic growth, demand for consumer goods that use titanium dioxide, such as paint and plastics, tends to increase, leading to higher prices During times of economic growth, demand for consumer goods that use titanium dioxide, such as paint and plastics, tends to increase, leading to higher pricestitanium dioxide price per ton. Conversely, during economic downturns, demand may decrease, resulting in lower prices.

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